groups » Antimalarial drug resistance » What strategies can effectively balance rapid antimalarial drug development with sustainable resistance management?
Malaria continues to threaten millions worldwide, with drug resistance posing a growing challenge. As we race to develop new treatments, we face a crucial dilemma: How do we create new drugs fast enough to save lives today without compromising our ability to fight malaria tomorrow?
ACTs drug discovery malaria resistance
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Shakira Babirye
19 Nov 2024
Awareness and stewardship Campaigns: Educate communities about rational antimalarial use and the importance of completing treatment courses just like AMR campaigns.
Use novel statistical and data science techniques like Predictive Modeling: Use computational models to anticipate resistance trends and guide drug design.
Rotational Strategies: Cycle antimalarial drugs with different mechanisms to minimize selective pressure on the parasite population.
Restrict Monotherapies: Avoid using single drugs (e.g., artemisinin alone) and ensure treatments involve combinations that are less prone to resistance.
Resistance Monitoring: Establish robust global surveillance networks to detect resistance early and adapt treatment protocols accordingly.
Genetic and Data-Driven Tools: Leverage molecular markers to identify and track resistant strains enabling precise resistance monitoring. Strengthen data collection systems with robust, real-time data visualization tools to detect emerging resistance patterns early and respond swiftly when situations escalate.
-
Shakira Babirye
19 Nov 2024
Awareness and stewardship Campaigns: Educate communities about rational antimalarial use and the importance of completing treatment courses just like AMR campaigns.
Use novel statistical and data science techniques like Predictive Modeling: Use computational models to anticipate resistance trends and guide drug design.
Rotational Strategies: Cycle antimalarial drugs with different mechanisms to minimize selective pressure on the parasite population.
Restrict Monotherapies: Avoid using single drugs (e.g., artemisinin alone) and ensure treatments involve combinations that are less prone to resistance.
Resistance Monitoring: Establish robust global surveillance networks to detect resistance early and adapt treatment protocols accordingly.
Genetic and Data-Driven Tools: Leverage molecular markers to identify and track resistant strains enabling precise resistance monitoring. Strengthen data collection systems with robust, real-time data visualization tools to detect emerging resistance patterns early and respond swiftly when situations escalate.
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